CK2 and PML: Regulating the Regulator
نویسندگان
چکیده
The PML protein induces senescence, and, upon oncogenic stress, its absence promotes cellular transformation. In this issue of Cell, Scaglioni et al. (2006) show that phosphorylation of PML by CK2, a kinase frequently activated in human cancers, promotes PML degradation. Therefore, pharmacological inhibition of CK2-induced PML loss could be used to offset tumor establishment.
منابع مشابه
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ورودعنوان ژورنال:
- Cell
دوره 126 شماره
صفحات -
تاریخ انتشار 2006